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KMID : 0369820070370010007
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 1 p.7 ~ p.14
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Development of Polymer Coating Method for Stable Stent Coating Using Chemical Bond Between Metal Surface and Polymer
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Nam Dae-Sik
Lee Woo-Kyoung
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Abstract
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To produce stable polymer coating layer using the interaction between metal stent and polymer layer. Ahx- HSAB was synthesized by coupling 6-aminoheanoic acid (Ahx) with N-Hydroxy succinimidyl 4-azidobenzonate (HSAB) containing photo reactive group. Then, Ahx-HSAB was applied to self-assembled monolayer (SAM) on TiO2-coated sur- face, since on end of Ahx-HSAB was carbocyl acid which was known to be able to interact with TiO2surface. That SAM layer was incubated in 1% polycaprolacton (PCL) solution and photoreacted by ultraviolet light (254 nm) to produce the chemical bond between SAM and polymer layer, followed by PCL polymer coating (~5μm) by method of spray coating, The surface change was investigated by measuring of contact angle of the surface. The contact angle values of stainless steel (SS) surface, TiO2-coated surface, SAM layer by Ahx-HSAB, photoreacted surface with PCL and PCL layer by spray coat- ing were 70.48 ± 1.89, 38.57 ± 3.31, 60.14 ± 2.21, 54.91 ± 2.70 and 56.47 ± 2.12, respectively. The stability of polymer layers was tested by incubation of PCL-coated plates in 0.1M PBS buffer (pH 7.4, 0.05% , Tween 80) with vigorous shaking (200 rpm). While the polymer layer prepared by these processes showed the intact surface morphology over 3 days, the polymer layers prepared by spray coating of PCL onto SS plate (control 1) and TiO2-coated SS plate (control 2) were peeled off in 3 days. Thus, the polymer coating method using SAM and photoreaction seems to be a effective method to obtain the stable polymer layer onto SS surface.
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KEYWORD
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SAM, Ster, Polymer coating, Photoreaction, PCL
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